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Applications>>Optogenetics &
Neuroscience |
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Lasers for Optogenetics & Neuroscience
& Gene Sequencing |
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Optogenetics is a booming multidisciplinary bioengineering
technology. It has the characteristic of high spatial-temporal
resolution and cell-type specific. It overcomes the
disadvantages of traditional methods of the activity control for
the cell and organism, and also provides a method
for the research of neuroscience. The research fields include
fundamental research of neural circuit, study and memory
research, habituation research, dyskinesia, sleep disorders,
parkinsonism, depressive disorder, anxiety disorder etc., and
many classic laboratory animal germ line (drosophila melanogaster,
nemathelminth, mice, Marmoset, and machin etc.).
Neuroscience is the
scientific study of the nervous system. It is currently an
interdisciplinary science that collaborates with other fields
such as chemistry, computer science, engineering, linguistics,
mathematics, medicine, genetics, and allied disciplines
including philosophy, physics, and psychology. It also exerts
influence on other fields, such as neuroinduction and neurology.
The scope of neuroscience has broadened to include different
approaches used to study the molecular, cellular, developmental,
structural, functional, evolutionary, computational, and medical
aspects of the nervous system.
Gene sequencing refers to the analysis of
specific DNA fragment base sequence to obtain biological genetic information. As
one of the most important biological analysis methods, DNA sequencing not only
provides important data for basic biological research such as genetic
information disclosure and gene expression regulation, but also plays an
important role in applied research such as gene diagnosis and gene therapy.
Changchun New Industries (CNI)
founded in 1996, is a manufacturer of solid-state and
diode laser systems. CNI laser features with high performance,
nice reliability, and specifically designed for OEM, scientific,
industrial and instrumentation use. In addition, CNI lasers are
ISO-9001, FDA, CE, RoHS and JQA certified. CNI can provide
different lasers for Optogenetics with free space and pigtailed
versions. Also the accessories used for Optogenetics are
available for a total solution from customers. |
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Features |
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■ CNI
provided high reliability lasers
■ All the
necessary accessories can be provided
■ Easy to
install and maintain
■ Customized
solution can be provided upon request |
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Related Lasers |
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Waveform Editable Laser Light Source |
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CNI developed the laser light source with
freely edited waveform. The model is fiber coupled with high stability,
easy for operation. It can be used in optogenetics, biomedical and other
applications that require laser modulation output.
In traditional optogenetics system
construction, the experimental system is complicated to set up, the
conditions cannot be precisely controlled and the maintenance of the
experimental system is difficult.
This new model integrates the self-developed
ultra-stable laser light source, high-precision light source control
system, intelligent human-computer interaction interface, human eye
safety protection and other functions, which greatly simplifies the
construction difficulty of optogenetics system. |
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◆ Intelligent
human-computer interface
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◆ Fiber interface
docking detection,
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◆ High
power stability<0.5%
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◆ Support
external trigger signal
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◆ Synchronizing signal
output
◆ USB port for program
update and reading data
◆ Single or dual
wavelength customized
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Angleadjustable, easy for experimental
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1ms-3600s/DC |
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465nm、473nm、589nm、594nm(customized upon request)
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Synchronizing signal port
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External signal port
(Trigger)
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BNC |
Custom signal input port
(Input)
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BNC |
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Laser light source quantity
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Single/ dual (customized
upon request)
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Datasheet |
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Accessories |
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Research achievements of CNI
laser for Optogenetics from customers |
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(1)
Optogenetic stimulation of a hippocampal engram activates fear
memory recall
(Nature, 484(7394): 381–385.
doi:10.1038/nature11028)
(CNI-473nm)
(2)
Ultrahigh accuracy imaging modality
for super-localization microscopy
(Nature Methods, VOL.10,2013,335)
(CNI-635nm
and
488nm)
(3) Optogenetic silencing of
locus coeruleus activity in mice impairs cognitive flexibility
in an attentional set-shifting task
(ORIGINALRESEARCH doi: 10.3389/fnbeh.2015.00286)
(CNI-589nm)
(4) Optogenetic Evidence That Pallidal Projections, Not Nigral
Projections, from the Nucleus Accumbens Core Are Necessary
for Reinstating Cocaine Seeking (The Journal of Neuroscience,
2013•33(34):13654–13662)
(CNI-561nm)
(5) Control of a specific
motor program by a small brain area in zebrafish
(Front Neural Circuits, 2013; 7:
67) (CNI-405nm
and 457nm)
(6) Fatal Neurological
Respiratory Insufficiency Is Common Among Viral Encephalitides
(Oxford Journals, 2013:208) (CNI-470nm)
(7) Temperature-dependent
Activation of Neurons by Continuous Near-infrared Laser
(Cell Biochemistry and
Biophysics,vol.53, 33-42,2009)(CNI-1064nm)
(8) Distal connectivity causes
summation and division across mouse visual cortex (Nature
Neuroscience, 2014,Volume:17,Pages:
30–32) (CNI-473nm)
(9) Remote activation of biomolecules in deep tissues using near-infrared-to-UV
upconversion nanotransducers
(PNAS,2012,109(22),8483-8488) (CNI-980nm)
(10) Viral Vector-Based
Techniques for Optogenetic Modulation In Vivo
(Viral Vector Approaches in
Neurobiology and Brain Diseases Neuromethods, Volume 82, 2014,
pp 289-310) (CNI-447nm)
(11) Optogenetic Inhibition
of Dorsal Medial Prefrontal Cortex Attenuates Stress-Induced
Reinstatement of Palatable Food Seeking in
Female Rats (The Journal of
Neuroscience, 2013, 33(1):214–226) (CNI-593.5nm)
(12) Glutamatergic Signaling
by Mesolimbic Dopamine Neurons in the Nucleus Accumbens
(The Journal of
Neuroscience, 2010, 30(20):7105-7110) (CNI-453nm)
(13)
Firing of Hippocampal Neurogliaform Cells Induces Suppression of
Synaptic Inhibition
(The Journal of
Neuroscience, 2014•34(4):1280–1292) (CNI-532nm)
(14) Intrinsic
Electrophysiology of Mouse Corticospinal Neurons: a
Class-Specific Triad of Spike-Related Properties
(Oxford Journals,
Volume 23,Issue 8,1965-1977) (CNI-473nm)
(15) Au–PLA nanocomposites
for photothermally controlled drug delivery (J. Mater. Chem. B,
2014,2, 409-417)(CNI-808nm)
(16) Synthesis of magnetic,
fluorescent and mesoporous core-shell-structured nanoparticles
for imaging, targeting and photodynamic
therapy (J. Mater. Chem., 2011,21,
11244-11252)(CNI-660nm)
(17) Asphaltene Adsorption
onto an Iron Surface: Combined Near-Infrared (NIR), Raman, and
AFM Study of the Kinetics,
Thermodynamics and Layer Structure
(Energy Fuels,2011,25(1), pp 189–196)(CNI-633nm)
(18) The electrophysiological
properties of voltage-gated potassium channels on cultivated
porcine retinal ganglion cells irradiated with
continuous near-infrared laser
(Chinese journal of ophthalmology 02/2012; 48(2):153-8).(CNI-845nm)
(19) High-resolution
simultaneous voltage and Ca2+imaging (J Physiol February 1,
2011.589(3)489-494)(CNI-543nm)
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